This post is my impression about St. Edward's guest speaker PhD Oleg Larionov. He presented his work on, “Total Syntheses of Amphidinolide V and Coraxeniolides.”
In the presentation, Larionov discussed the series of steps taken in his research. Larionov began with recognizing the synthesis of Amphidinolide in marine plant life. The minuscule amount derived from nature provided reason in forming total synthesis of Amphidinolide. The process of total synthesis was completed in a series of systematic steps. The first step included “a sequence of ring-closing alkyne metathesis” binding with cycloalkyne and ethene to form the macrocyclic skeleton. In return, the vicinal exo-methylene branches were developed. The process was successful in total synthesis and had direct correlation with the “cytotoxic marine natural product amphidinolide V.” The works of Larionov provides further intuition for later projects involving ring-closing alkyne metathesis.
Listening to Larionov speak was somewhat a demo of what I know I’ll be able to understand either eight years from now, or potentially four years from now. The in-depth knowledge implemented, has me look forward toward my years in graduate school; knowing one day I’ll be able to speak fluid in scientific theology. This presentation has also showed me the amount of time and dedication that has to be put into a research project. Even though Larionov research turned out successful, I am sure there have been a lot of flaws along the way. I am also sure some researchers could not fix these flaws and are force to go back to the drawing board, but you know I think that’s what drives scientist and researchers. If I’ve learned anything from this presentation it is a researcher, in any field, has their own motivation to research and wants to educate others in their interest.
In the presentation, Larionov discussed the series of steps taken in his research. Larionov began with recognizing the synthesis of Amphidinolide in marine plant life. The minuscule amount derived from nature provided reason in forming total synthesis of Amphidinolide. The process of total synthesis was completed in a series of systematic steps. The first step included “a sequence of ring-closing alkyne metathesis” binding with cycloalkyne and ethene to form the macrocyclic skeleton. In return, the vicinal exo-methylene branches were developed. The process was successful in total synthesis and had direct correlation with the “cytotoxic marine natural product amphidinolide V.” The works of Larionov provides further intuition for later projects involving ring-closing alkyne metathesis.
Listening to Larionov speak was somewhat a demo of what I know I’ll be able to understand either eight years from now, or potentially four years from now. The in-depth knowledge implemented, has me look forward toward my years in graduate school; knowing one day I’ll be able to speak fluid in scientific theology. This presentation has also showed me the amount of time and dedication that has to be put into a research project. Even though Larionov research turned out successful, I am sure there have been a lot of flaws along the way. I am also sure some researchers could not fix these flaws and are force to go back to the drawing board, but you know I think that’s what drives scientist and researchers. If I’ve learned anything from this presentation it is a researcher, in any field, has their own motivation to research and wants to educate others in their interest.
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